ITPR1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- calcium ion transport [NAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate-mediated signaling [ISS, TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- negative regulation of calcium-mediated signaling [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of insulin secretion [TAS]
- release of sequestered calcium ion into cytosol [ISS]
- response to hypoxia [IDA]
- signal transduction [NAS, TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FKBP1A
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- SMAD protein complex assembly [IDA]
- T cell activation [NAS]
- amyloid fibril formation [IDA]
- calcium ion transmembrane transport [NAS]
- chaperone-mediated protein folding [IBA]
- extracellular fibril organization [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [NAS]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of activin receptor signaling pathway [IDA]
- regulation of amyloid precursor protein catabolic process [IGI]
- regulation of immune response [IMP]
- regulation of protein localization [IGI]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, ISS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.
Ca2+ release from the sarcoplasmic reticulum (SR) by the IP3 receptors (IP3Rs) crucially regulates diverse cell signalling processes from reproduction to apoptosis. Release from the IP3R may be modulated by endogenous proteins associated with the receptor, such as the 12 kDa FK506-binding protein (FKBP12), either directly or indirectly by inhibition of the phosphatase calcineurin. Here, we report that, in addition ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITPR1 FKBP1A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID