BAIT
TSC2
LAM, PPP1R160, TSC4
tuberous sclerosis 2
GO Process (28)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell cycle arrest [TAS]
- endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- negative regulation of TOR signaling [IBA]
- negative regulation of Wnt signaling pathway [IBA]
- negative regulation of cell proliferation [ISS]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISS]
- negative regulation of protein kinase B signaling [IBA, ISS]
- negative regulation of protein kinase activity [ISS]
- neural tube closure [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [ISS]
- positive regulation of Ras GTPase activity [IBA]
- protein import into nucleus [ISS]
- protein kinase B signaling [ISS]
- protein localization [ISS]
- regulation of cell cycle [IBA]
- regulation of endocytosis [ISS]
- regulation of insulin receptor signaling pathway [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB5A
RAB5
RAB5A, member RAS oncogene family
GO Process (13)
GO Function (4)
GO Component (16)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rab protein signal transduction [IBA]
- blood coagulation [TAS]
- early endosome to late endosome transport [IMP]
- endocytosis [IDA]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [IMP]
- receptor internalization involved in canonical Wnt signaling pathway [IMP]
- regulation of endocytosis [IBA]
- regulation of endosome size [IMP]
- regulation of filopodium assembly [IDA]
- regulation of synaptic vesicle exocytosis [IMP]
- synaptic vesicle recycling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- axon terminus [ISS]
- cytoplasm [IDA]
- cytoplasmic side of early endosome membrane [IMP]
- cytosol [IDA]
- dendrite [ISS]
- early endosome [IDA]
- endocytic vesicle [IBA]
- endosome [ISS]
- endosome membrane [TAS]
- extracellular vesicular exosome [IDA]
- neuronal cell body [ISS]
- plasma membrane [IBA]
- somatodendritic compartment [IDA]
- synaptic vesicle [ISS]
- terminal bouton [IDA]
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin.
Mutations of the TSC1 and TSC2 genes give rise to the clinical disorder of tuberous sclerosis characterized by the development of hamartomas predominantly affecting the central nervous system, kidney, skin, lung, and heart. The function of the gene products, hamartin and tuberin, is not well understood but we have previously suggested a role in vesicular transport. To define the subcellular ... [more]
Arch. Biochem. Biophys. Aug. 15, 2002; 404(2);210-7 [Pubmed: 12147258]
Throughput
- Low Throughput
Curated By
- BioGRID