BAIT
TSC2
Rc
tuberous sclerosis 2
GO Process (34)
GO Function (7)
GO Component (18)
Gene Ontology Biological Process
- acute-phase response [IMP]
- cell projection organization [IGI, IMP]
- cellular response to insulin stimulus [ISO]
- establishment of protein localization [IMP]
- glucose import [ISO]
- heart development [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of TOR signaling [IDA, ISO]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein kinase B signaling [IBA, ISO]
- negative regulation of protein kinase activity [ISO]
- neural tube closure [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive chemotaxis [ISO]
- positive regulation of Rab GTPase activity [TAS]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein heterooligomerization [IDA, IMP]
- protein homooligomerization [IDA, IMP]
- protein import into nucleus [ISO]
- protein kinase B signaling [ISO]
- protein localization [ISO]
- protein transport into plasma membrane raft [ISO]
- regulation of cell cycle [IMP]
- regulation of endocytosis [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to hypoxia [ISO]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- TSC1-TSC2 complex [IBA, ISO]
- caveola [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- dendrite [IDA]
- growth cone [IDA]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- protein complex [IDA]
Rattus norvegicus
PREY
TSC1
LAM, TSC
tuberous sclerosis 1
GO Process (17)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell cycle arrest [TAS]
- cell-matrix adhesion [IMP]
- insulin receptor signaling pathway [TAS]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- protein stabilization [IDA]
- rRNA export from nucleus [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [IMP]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of stress fiber assembly [IDA]
- regulation of translation [IDA]
- response to insulin [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin.
Mutations of the TSC1 and TSC2 genes give rise to the clinical disorder of tuberous sclerosis characterized by the development of hamartomas predominantly affecting the central nervous system, kidney, skin, lung, and heart. The function of the gene products, hamartin and tuberin, is not well understood but we have previously suggested a role in vesicular transport. To define the subcellular ... [more]
Arch. Biochem. Biophys. Aug. 15, 2002; 404(2);210-7 [Pubmed: 12147258]
Throughput
- Low Throughput
Curated By
- BioGRID