Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.

Saito K, Araki Y, Kontani K, Nishina H, Katada T

The Ras-homologous GTPase Rheb that is conserved from yeast to human appears to be involved not only in cell growth but also in nutrient uptake. Recent biochemical analysis revealed that tuberous sclerosis complex (TSC), a GTPase-activating protein (GAP), deactivates Rheb and that phosphatidylinositol 3'-kinase (PI3k)-Akt/PKB kinase pathway activates Rheb through inhibition of the GAP-mediated deactivation. Although mammalian target of rapamycin ... [more]

J. Biochem. Mar. 01, 2005; 137(3);423-30 [Pubmed: 15809346]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

RHEB

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTP binding [ISS]GTPase activity [TAS]protein binding [IPI]

Gene Ontology Cellular Component

RAB9A

Gene Ontology Biological Process

Gene Ontology Molecular Function

GDP binding [IDA]GTP binding [IDA]GTPase activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

Co-localization

Publication

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.

Throughput

Curated By

GTP binding [ISS]
GTPase activity [TAS]
protein binding [IPI]

GDP binding [IDA]
GTP binding [IDA]
GTPase activity [IDA]
protein binding [IPI]