BAIT
ADRA1A
ADRA1C, ADRA1L1, ALPHA1AAR
adrenoceptor alpha 1A
GO Process (22)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [ISS]
- adrenergic receptor signaling pathway [ISS, NAS, TAS]
- aging [ISS]
- apoptotic process [TAS]
- calcium ion transport into cytosol [ISS]
- cell-cell signaling [TAS]
- intracellular signal transduction [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell proliferation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of action potential [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of vasoconstriction [ISS]
- response to drug [ISS]
- response to hormone [ISS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCN1B
ATFB13, BRGDA5, GEFSP1
sodium channel, voltage-gated, type I, beta subunit
GO Process (18)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- axon guidance [ISS, TAS]
- cardiac conduction [ISS]
- cardiac muscle cell action potential involved in contraction [IMP]
- cardiac muscle contraction [IMP]
- corticospinal neuron axon guidance [ISS]
- locomotion [ISS]
- membrane depolarization [IDA]
- membrane depolarization during Purkinje myocyte cell action potential [IMP]
- membrane depolarization during cardiac muscle cell action potential [ISS]
- neuronal action potential propagation [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of sodium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISS]
- sodium ion transmembrane transport [IDA, IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- sodium channel inhibitor activity [ISS]
- sodium channel regulator activity [IDA]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP]
- sodium channel inhibitor activity [ISS]
- sodium channel regulator activity [IDA]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID