BAIT
AGTR1
AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
angiotensin II receptor, type 1
GO Process (27)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- Rho protein signal transduction [IDA]
- angiotensin-activated signaling pathway [IDA]
- calcium-mediated signaling [IDA]
- cell chemotaxis [IDA]
- kidney development [IMP]
- low-density lipoprotein particle remodeling [NAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [NAS]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IPI]
- positive regulation of NAD(P)H oxidase activity [TAS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol esterification [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of inflammatory response [TAS]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of phospholipase A2 activity [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- regulation of blood vessel size by renin-angiotensin [IC]
- regulation of cell growth [NAS]
- regulation of cell proliferation [NAS]
- regulation of inflammatory response [IC]
- regulation of renal sodium excretion [NAS]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC]
- regulation of vasoconstriction [IC, IDA, NAS]
- regulation of vasodilation [IC]
- renin-angiotensin regulation of aldosterone production [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GOT1
ASTQTL1, GIG18, cAspAT, cCAT
glutamic-oxaloacetic transaminase 1, soluble
GO Process (16)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [ISS]
- L-methionine biosynthetic process from methylthioadenosine [TAS]
- aspartate catabolic process [IDA]
- aspartate metabolic process [ISS]
- carbohydrate metabolic process [TAS]
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- cellular response to insulin stimulus [IEP]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- glutamate metabolic process [ISS]
- glycerol biosynthetic process [ISS]
- polyamine metabolic process [TAS]
- response to glucocorticoid [IEP]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID