BAIT
BDKRB2
B2R, BK-2, BK2, BKR2, BRB2
bradykinin receptor B2
GO Process (10)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- arachidonic acid secretion [IDA]
- blood circulation [NAS]
- cell surface receptor signaling pathway [TAS]
- inflammatory response [IC]
- metabolic process [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- regulation of vascular permeability [IC]
- regulation of vasoconstriction [IC]
- smooth muscle contraction [IC]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
INF2
C14orf151, C14orf173, CMTDIE, FSGS5, pp9484, hCG_2029577
inverted formin, FH2 and WH2 domain containing
GO Process (1)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]
Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]
Throughput
- High Throughput
Additional Notes
- interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay
Curated By
- BioGRID