BAIT

LTB4R2

BLT2, BLTR2, JULF2, KPG_004, LTB4-R 2, LTB4-R2, NOP9

leukotriene B4 receptor 2

Arachidonic Acid Pathway Project

GO Process (2)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

chemotaxis [TAS]

negative regulation of adenylate cyclase activity [TAS]

Gene Ontology Molecular Function

leukotriene receptor activity [TAS]

Gene Ontology Cellular Component

integral component of plasma membrane [TAS]

plasma membrane [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

HLA-A

HLAA, DAQB-90C11.16-002

major histocompatibility complex, class I, A

GO Process (17)

GO Function (7)

GO Component (15)

Gene Ontology Biological Process

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [IDA]

antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]

antigen processing and presentation of peptide antigen via MHC class I [TAS]

cytokine-mediated signaling pathway [TAS]

detection of bacterium [IMP]

immune response [IMP, NAS]

interferon-gamma-mediated signaling pathway [TAS]

positive regulation of T cell mediated cytotoxicity [IDA]

positive regulation of interferon-gamma production [IDA]

positive regulation of memory T cell activation [IDA]

protection from natural killer cell mediated cytotoxicity [IDA]

regulation of defense response to virus by virus [TAS]

regulation of immune response [TAS]

type I interferon signaling pathway [TAS]

viral process [TAS]

Gene Ontology Molecular Function

T cell receptor binding [IDA]
TAP binding [IDA]
beta-2-microglobulin binding [IDA, ISS]
peptide antigen binding [IBA, IDA, ISS]
poly(A) RNA binding [IDA]
protein binding [IPI]
receptor binding [IBA, IPI]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandia J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morato X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Przulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I

G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) ... [more]

Mol. Syst. Biol. Dec. 15, 2016; 13(3);918 [Pubmed: 28298427]

Throughput

High Throughput

Additional Notes

interaction identified using a modified split-ubiquitin membrane yeast two-hybrid (MYTH) assay

Curated By

BioGRID