BAIT
EPAS1
ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
endothelial PAS domain protein 1
GO Process (6)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [IDA, TAS]
- myoblast fate commitment [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ALOX15
12-LOX, 15-LOX-1, 15LOX-1
arachidonate 15-lipoxygenase
GO Process (21)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- apoptotic cell clearance [ISS]
- arachidonic acid metabolic process [IDA, NAS, TAS]
- bone mineralization [ISS]
- cellular response to calcium ion [IDA]
- cellular response to interleukin-13 [IMP]
- hepoxilin biosynthetic process [ISS]
- inflammatory response [TAS]
- leukotriene metabolic process [TAS]
- lipoxin A4 biosynthetic process [ISS]
- lipoxygenase pathway [IDA, TAS]
- negative regulation of adaptive immune response [ISS]
- ossification [ISS]
- phosphatidylethanolamine biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- regulation of engulfment of apoptotic cell [ISS]
- regulation of peroxisome proliferator activated receptor signaling pathway [ISS]
- response to endoplasmic reticulum stress [ISS]
- small molecule metabolic process [TAS]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cancer therapies. Here we identify an intrinsic vulnerability to ferroptosis associated with the unique metabolic state in CCCs. This vulnerability transcends lineage and genetic landscape, ... [more]
Nat Commun Dec. 08, 2018; 10(1);1617 [Pubmed: 30962421]
Throughput
- Low Throughput
Ontology Terms
- cell component: cellular response to drug (GO:0035690)
Additional Notes
- CRISPR method
- overexpression restores ferroptosis-inducing chemical sensitivity in a CRISPR generated HIF2alpha mutant
Curated By
- BioGRID