BAIT
PACSIN1
SDPI, RP11-375E1__A.1
protein kinase C and casein kinase substrate in neurons 1
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- cytoskeleton organization [IBA]
- establishment of protein localization to plasma membrane [ISS]
- membrane tubulation [IDA]
- neuron projection morphogenesis [IBA, ISS]
- positive regulation of dendrite development [ISS]
- protein localization to membrane [ISS]
- regulation of endocytosis [IBA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PACSIN1
SDPI, RP11-375E1__A.1
protein kinase C and casein kinase substrate in neurons 1
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- cytoskeleton organization [IBA]
- establishment of protein localization to plasma membrane [ISS]
- membrane tubulation [IDA]
- neuron projection morphogenesis [IBA, ISS]
- positive regulation of dendrite development [ISS]
- protein localization to membrane [ISS]
- regulation of endocytosis [IBA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.
The PACSINs are a family of cytoplasmic phosphoproteins that play a role in vesicle formation and transport. We report the cloning and cDNA sequencing of PACSIN 3 and the analysis of all three PACSIN isoforms with regard to tissue distribution, ligand binding properties and influence on endocytosis. PACSIN 3 differs from the other family members in having a short proline-rich ... [more]
J. Cell. Sci. Dec. 01, 2000; 113(0);4511-21 [Pubmed: 11082044]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PACSIN1 PACSIN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID