BAIT
PACSIN1
SDPI, RP11-375E1__A.1
protein kinase C and casein kinase substrate in neurons 1
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- cytoskeleton organization [IBA]
- establishment of protein localization to plasma membrane [ISS]
- membrane tubulation [IDA]
- neuron projection morphogenesis [IBA, ISS]
- positive regulation of dendrite development [ISS]
- protein localization to membrane [ISS]
- regulation of endocytosis [IBA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PACSIN1
SDPI, RP11-375E1__A.1
protein kinase C and casein kinase substrate in neurons 1
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- cytoskeleton organization [IBA]
- establishment of protein localization to plasma membrane [ISS]
- membrane tubulation [IDA]
- neuron projection morphogenesis [IBA, ISS]
- positive regulation of dendrite development [ISS]
- protein localization to membrane [ISS]
- regulation of endocytosis [IBA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.
The PACSINs are a family of cytoplasmic phosphoproteins that play a role in vesicle formation and transport. We report the cloning and cDNA sequencing of PACSIN 3 and the analysis of all three PACSIN isoforms with regard to tissue distribution, ligand binding properties and influence on endocytosis. PACSIN 3 differs from the other family members in having a short proline-rich ... [more]
J. Cell. Sci. Dec. 01, 2000; 113(0);4511-21 [Pubmed: 11082044]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PACSIN1 PACSIN1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID