PTPN6
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- T cell costimulation [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell differentiation [IDA]
- cell proliferation [IDA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- negative regulation of cell proliferation [NAS]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- protein dephosphorylation [IDA]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
NOS1
Gene Ontology Biological Process
- arginine catabolic process [IC]
- blood coagulation [TAS]
- cellular response to growth factor stimulus [ISS]
- exogenous drug catabolic process [ISS]
- interaction with host [TAS]
- multicellular organismal response to stress [IMP]
- myoblast fusion [TAS]
- negative regulation of blood pressure [IBA]
- negative regulation of calcium ion transport [ISS]
- negative regulation of calcium ion transport into cytosol [TAS]
- negative regulation of hydrolase activity [ISS]
- negative regulation of potassium ion transport [ISS]
- negative regulation of serotonin uptake [ISS]
- neurotransmitter biosynthetic process [TAS]
- nitric oxide biosynthetic process [IBA, ISS]
- nitric oxide mediated signal transduction [IBA]
- peptidyl-cysteine S-nitrosylation [ISS]
- phagosome maturation [TAS]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [ISS]
- positive regulation of sodium ion transmembrane transport [ISS]
- positive regulation of the force of heart contraction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of vasodilation [IDA, IMP]
- regulation of cardiac muscle contraction [TAS]
- regulation of sodium ion transport [ISS]
- response to heat [IDA]
- response to hypoxia [IEP]
- striated muscle contraction [ISS]
Gene Ontology Molecular Function- FMN binding [ISS]
- NADP binding [ISS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [TAS]
- cadmium ion binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- ion channel binding [ISS]
- nitric-oxide synthase activity [IBA, ISS]
- oxidoreductase activity [IBA]
- protein binding [IPI]
- scaffold protein binding [ISS]
- sodium channel regulator activity [ISS]
- tetrahydrobiopterin binding [NAS]
- FMN binding [ISS]
- NADP binding [ISS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [TAS]
- cadmium ion binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- ion channel binding [ISS]
- nitric-oxide synthase activity [IBA, ISS]
- oxidoreductase activity [IBA]
- protein binding [IPI]
- scaffold protein binding [ISS]
- sodium channel regulator activity [ISS]
- tetrahydrobiopterin binding [NAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuronal nitric oxide synthase: a substrate for SHP-1 involved in sst2 somatostatin receptor growth inhibitory signaling.
Somatostatin receptor sst2 is an inhibitory G protein-coupled receptor, which inhibits normal and tumor cell growth by a mechanism involving the tyrosine phosphatase SHP-1. We reported previously that SHP-1 associates transiently with and is activated by sst2 and is a critical component for sst2 growth inhibitory signaling. Here, we demonstrate that in Chinese hamster ovary cells expressing sst2, SHP-1 is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID