BAIT
ARHGAP21
ARHGAP10, RP11-324E23.2
Rho GTPase activating protein 21
GO Process (5)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HMGA2
BABL, HMGI-C, HMGIC, LIPO, STQTL9
high mobility group AT-hook 2
GO Process (42)
GO Function (19)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA damage response, detection of DNA damage [IDA]
- base-excision repair [IDA]
- chondrocyte differentiation [IDA]
- chondrocyte proliferation [IDA]
- chromatin organization [TAS]
- chromosome breakage [IDA]
- endodermal cell differentiation [IMP]
- epithelial to mesenchymal transition [IMP]
- fat cell differentiation [IMP]
- heterochromatin assembly [IDA]
- histone H2A-S139 phosphorylation [IDA]
- mesenchymal cell differentiation [IMP]
- mesodermal cell differentiation [IMP]
- mesodermal-endodermal cell signaling [IMP]
- mitotic G2 DNA damage checkpoint [IDA]
- multicellular organismal development [TAS]
- negative regulation by host of viral transcription [IDA]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of double-strand break repair via nonhomologous end joining [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- oncogene-induced cell senescence [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular response to X-ray [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of response to DNA damage stimulus [IDA]
- positive regulation of stem cell proliferation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of cell cycle process [IDA]
- regulation of cellular response to drug [IDA]
- regulation of stem cell maintenance [IMP, TAS]
- regulation of transcription, DNA-templated [IMP]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- stem cell differentiation [IEP]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a family-wide characterization of substrate specificities, interactomes and localization, we reveal at the systems level how RhoGEFs and ... [more]
Nat. Cell Biol. Dec. 01, 2019; 22(4);498-511 [Pubmed: 32203420]
Quantitative Score
- 2.042687167 [CompPASS Z-score]
Throughput
- High Throughput
Additional Notes
- prey proteins were classified into confidence-level categories of gold (highest confidence), silver or bronze based on various criteria
- tagged bait proteins were affinity purified and associated proteins identified by mass spectrometry
- the score provided is the CompPASS Z-score
- this interaction was classified by the authors as being in the bronze list
Curated By
- BioGRID