BAIT
NR5A1
AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, RP11-101K10.1
nuclear receptor subfamily 5, group A, member 1
GO Process (8)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- gene expression [TAS]
- intracellular receptor signaling pathway [TAS]
- positive regulation of male gonad development [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- primary sex determination [TAS]
- regulation of steroid biosynthetic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- phospholipid binding [IDA]
- protein binding [IPI]
- transcription coactivator activity [TAS]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- phospholipid binding [IDA]
- protein binding [IPI]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IDA]
Homo sapiens
PREY
SOX9
CMD1, CMPD1, SRA1
SRY (sex determining region Y)-box 9
GO Process (70)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- Sertoli cell differentiation [ISS]
- cAMP-mediated signaling [IDA]
- cartilage condensation [ISS]
- cartilage development [ISS]
- cell fate specification [ISS]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to heparin [ISS]
- cellular response to interleukin-1 [IEP]
- cellular response to mechanical stimulus [ISS]
- cellular response to retinoic acid [IEP]
- cellular response to transforming growth factor beta stimulus [IDA]
- chondrocyte differentiation involved in endochondral bone morphogenesis [IMP]
- chondrocyte hypertrophy [ISS]
- chromatin remodeling [IDA]
- cochlea morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [ISS]
- epithelial cell proliferation involved in prostatic bud elongation [ISS]
- epithelial to mesenchymal transition [ISS]
- hair follicle development [ISS]
- heart valve development [ISS]
- heart valve morphogenesis [ISS]
- intestinal epithelial structure maintenance [ISS]
- male germ-line sex determination [ISS]
- male gonad development [IEP, IMP]
- metanephric nephron tubule formation [ISS]
- morphogenesis of a branching epithelium [ISS]
- negative regulation of apoptotic process [IMP, ISS]
- negative regulation of biomineral tissue development [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of epithelial cell proliferation [ISS]
- negative regulation of immune system process [ISS]
- negative regulation of myoblast differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of photoreceptor cell differentiation [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome assembly [IDA]
- otic vesicle formation [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cartilage development [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of chondrocyte differentiation [IDA, IMP]
- positive regulation of epithelial cell differentiation [ISS]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of epithelial cell proliferation [IEP, ISS]
- positive regulation of kidney development [ISS]
- positive regulation of male gonad development [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of mesenchymal stem cell differentiation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- prostate gland development [IEP]
- protein complex assembly [IDA]
- regulation of apoptotic process [ISS]
- regulation of cell cycle process [IMP]
- regulation of cell proliferation [ISS]
- regulation of cell proliferation involved in tissue homeostasis [ISS]
- renal vesicle induction [ISS]
- retina development in camera-type eye [ISS]
- retinal rod cell differentiation [ISS]
- signal transduction [ISS]
- skeletal system development [IMP]
- somatic stem cell maintenance [ISS]
- spermatogenesis [ISS]
- tissue homeostasis [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Muellerian hormone gene.
For proper male sexual differentiation, anti-Muellerian hormone (AMH) must be tightly regulated during embryonic development to promote regression of the Muellerian duct. However, the molecular mechanisms specifying the onset of AMH in male mammals are not yet clearly defined. A DNA-binding element for the steroidogenic factor 1 (SF-1), a member of the orphan nuclear receptor family, located in the AMH ... [more]
Mol. Cell. Biol. Nov. 01, 1998; 18(11);6653-65 [Pubmed: 9774680]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOX9 NR5A1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SOX9 NR5A1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID