BAIT
IFNL1
IL-29, IL29
interferon, lambda 1
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- defense response to virus [IDA]
- negative regulation of T cell differentiation [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of interleukin-13 production [IDA]
- negative regulation of interleukin-5 production [IDA]
- negative regulation of memory T cell differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of type 2 immune response [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MHC class I biosynthetic process [IDA]
- positive regulation of immune response [TAS]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of tyrosine phosphorylation of STAT protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MOK
RAGE, RAGE-1, RAGE1, STK30
MOK protein kinase
GO Process (1)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- phenotype: viability (PATO:0000169)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic positive genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI > 1.11
Curated By
- BioGRID