BAIT
IFNL3
IL-28B, IL28B, IL28C
interferon, lambda 3
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
IL12RB1
CD212, IL-12R-BETA1, IL12RB, IMD30
interleukin 12 receptor, beta 1
GO Process (13)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cellular response to interferon-gamma [IDA]
- cytokine-mediated signaling pathway [TAS]
- interleukin-12-mediated signaling pathway [IDA]
- interleukin-23-mediated signaling pathway [IDA]
- positive regulation of T cell mediated cytotoxicity [ISS]
- positive regulation of T-helper 1 type immune response [IDA, ISS]
- positive regulation of T-helper 17 cell lineage commitment [ISS]
- positive regulation of T-helper 17 type immune response [ISS]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of defense response to virus by host [IDA, ISS]
- positive regulation of interferon-gamma production [IDA, IMP]
- positive regulation of memory T cell differentiation [ISS]
- signal transduction [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- phenotype: viability (PATO:0000169)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic positive genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI > 1.11
Curated By
- BioGRID