BAIT
IL6
BSF2, HGF, HSF, IFNB2, IL-6
interleukin 6
GO Process (51)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- T-helper 17 cell lineage commitment [ISS]
- acute-phase response [TAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to lipopolysaccharide [IMP]
- cytokine-mediated signaling pathway [IDA]
- defense response to Gram-negative bacterium [IEP]
- defense response to Gram-positive bacterium [IEP]
- defense response to virus [IDA]
- endocrine pancreas development [ISS]
- glucagon secretion [ISS]
- hepatic immune response [IDA, TAS]
- humoral immune response [IC]
- inflammatory response [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- monocyte chemotaxis [IC]
- negative regulation of apoptotic process [IDA]
- negative regulation of chemokine biosynthetic process [ISS]
- negative regulation of collagen biosynthetic process [IDA]
- negative regulation of fat cell differentiation [NAS]
- negative regulation of lipid storage [NAS]
- neuron projection development [IMP]
- neutrophil apoptotic process [IDA]
- neutrophil mediated immunity [IC]
- platelet activation [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of STAT protein import into nucleus [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of acute inflammatory response [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of chemokine production [IDA, IMP]
- positive regulation of immunoglobulin secretion [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of leukocyte chemotaxis [IC]
- positive regulation of osteoblast differentiation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of translation [IDA]
- positive regulation of type B pancreatic cell apoptotic process [TAS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of angiogenesis [IC]
- regulation of vascular endothelial growth factor production [IDA]
- response to glucocorticoid [IDA]
- response to peptidoglycan [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
JAK1
JAK1A, JAK1B, JTK3
Janus kinase 1
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- interleukin-2-mediated signaling pathway [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- response to antibiotic [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- phenotype: viability (PATO:0000169)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic positive genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI > 1.11
Curated By
- BioGRID