BAIT
ATM
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
ATM serine/threonine kinase
GO Process (23)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA repair [TAS]
- cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- histone mRNA catabolic process [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of B cell proliferation [IMP]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IMP]
- pre-B cell allelic exclusion [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- reciprocal meiotic recombination [TAS]
- replicative senescence [IMP]
- response to ionizing radiation [IDA]
- signal transduction [TAS]
- signal transduction involved in mitotic G2 DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IL6R
CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80
interleukin 6 receptor
GO Process (25)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- acute-phase response [TAS]
- ciliary neurotrophic factor-mediated signaling pathway [IMP]
- cytokine-mediated signaling pathway [IDA]
- defense response to Gram-negative bacterium [IEP]
- defense response to Gram-positive bacterium [IEP]
- endocrine pancreas development [IC, IMP]
- extrinsic apoptotic signaling pathway [TAS]
- hepatic immune response [TAS]
- interleukin-6-mediated signaling pathway [IMP]
- monocyte chemotaxis [IC]
- negative regulation of collagen biosynthetic process [IDA]
- negative regulation of interleukin-8 production [IEP]
- neutrophil mediated immunity [IC]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of activation of Janus kinase activity [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of chemokine production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of leukocyte chemotaxis [IC, TAS]
- positive regulation of osteoblast differentiation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- response to cytokine [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- phenotype: viability (PATO:0000169)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic negative genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI < -0.84
Curated By
- BioGRID