TLK-1
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of protein kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein methylation [IMP]
- protein phosphorylation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IPL1
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore [IMP]
- chromosome segregation [IMP]
- homologous chromosome segregation [IMP]
- meiotic sister chromatid segregation [IMP]
- mitotic DNA integrity checkpoint [IGI]
- mitotic spindle disassembly [IMP]
- negative regulation of protein import into nucleus during spindle assembly checkpoint [IMP]
- positive regulation of spindle checkpoint [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cytokinesis [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo.
The Aurora kinases comprise an evolutionarily conserved protein family that is required for a variety of cell division events, including spindle assembly, chromosome segregation, and cytokinesis. Emerging evidence suggests that once phosphorylated, a subset of Aurora substrates can enhance Aurora kinase activity. Our previous work revealed that the Caenorhabditis elegans Tousled-like kinase TLK-1 is a substrate and activator of the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID