PLA2G4C
Gene Ontology Biological Process
- arachidonic acid metabolic process [NAS]
- glycerophospholipid biosynthetic process [TAS]
- glycerophospholipid catabolic process [IDA]
- inflammatory response [NAS]
- intracellular signal transduction [NAS]
- parturition [NAS]
- phosphatidylcholine acyl-chain remodeling [TAS]
- phosphatidylethanolamine acyl-chain remodeling [TAS]
- phosphatidylinositol acyl-chain remodeling [TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
S100A10
Gene Ontology Biological Process
- establishment of protein localization to plasma membrane [IDA]
- membrane budding [IDA]
- membrane raft assembly [IDA]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of stress fiber assembly [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- protein heterotetramerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2.
Using a two hybrid system screen of a human cDNA library, we have found that p11, a unique member of the S100 family of calcium-binding proteins, interacts with the carboxyl region of the 85-kDa cytosolic phospholipase A2 (cPLA2). p11 synthesized in a cell-free system interacts with cPLA2 in vitro. The p11-cPLA2 complex is detectable from a human bronchial epithelial cell ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID