BAIT
BMP2
BDA2, BMP2A
bone morphogenetic protein 2
GO Process (79)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IEP, IMP, TAS]
- BMP signaling pathway involved in heart induction [IDA]
- Notch signaling pathway [ISS]
- SMAD protein signal transduction [IDA]
- activation of MAPK activity [IDA]
- atrioventricular valve morphogenesis [ISS]
- bone mineralization [ISS]
- bone mineralization involved in bone maturation [IDA]
- branching involved in ureteric bud morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue morphogenesis [ISS]
- cardiocyte differentiation [IDA, IMP]
- cell fate commitment [ISS]
- cell-cell signaling [TAS]
- cellular response to BMP stimulus [IDA]
- chondrocyte differentiation [IDA]
- corticotropin hormone secreting cell differentiation [ISS]
- embryo development [ISS]
- embryonic heart tube anterior/posterior pattern specification [ISS]
- endocardial cushion morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular matrix organization [TAS]
- heart development [ISS]
- in utero embryonic development [ISS]
- inflammatory response [ISS]
- inner ear development [ISS]
- mesenchymal cell differentiation [IDA]
- mesenchymal cell proliferation involved in ureteric bud development [ISS]
- mesenchyme development [IMP]
- negative regulation of Wnt signaling pathway involved in heart development [IDA]
- negative regulation of aldosterone biosynthetic process [IDA]
- negative regulation of calcium-independent cell-cell adhesion [IDA]
- negative regulation of canonical Wnt signaling pathway [IEP]
- negative regulation of cardiac muscle cell differentiation [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cortisol biosynthetic process [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis of dentin-containing tooth [ISS]
- organ morphogenesis [ISS]
- osteoblast differentiation [IDA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- pericardium development [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of Wnt signaling pathway by BMP signaling pathway [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of bone mineralization [IDA]
- positive regulation of cartilage development [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of fat cell differentiation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of neuron differentiation [ISS]
- positive regulation of odontogenesis [ISS]
- positive regulation of ossification [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of phosphatase activity [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to hypoxia [ISS]
- skeletal system development [TAS]
- telencephalon development [IDA]
- telencephalon regionalization [ISS]
- thyroid-stimulating hormone-secreting cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BMPR2
BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (30)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II.
Bone morphogenetic protein-2 (BMP-2) induces bone formation and regeneration in adult vertebrates and regulates important developmental processes in all animals. BMP-2 is a homodimeric cysteine knot protein that, as a member of the transforming growth factor-beta (TGF-beta) superfamily, signals by oligomerizing type I and type II receptor serine-kinases in the cell membrane. The binding epitopes of BMP-2 for BMPR-IA (type ... [more]
EMBO J. Jul. 03, 2000; 19(13);3314-24 [Pubmed: 10880444]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BMP2 BMPR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 245171 | |
| BMP2 BMPR2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| BMPR2 BMP2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID