BAIT

HULC

HCCAT1, LINC00078, NCRNA00078
hepatocellular carcinoma up-regulated long non-coding RNA
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

LDHA

GSD11, HEL-S-133P, LDH1, LDHM, PIG19
lactate dehydrogenase A
Human Papilloma Virus (HPV) Project
Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N

Interacting with proteins is a crucial way for long noncoding RNAs (lncRNAs) to exert their biological responses. Here we report a high throughput strategy to characterize lncRNA interacting proteins in vivo by combining tobramycin affinity purification and mass spectrometric analysis (TOBAP-MS). Using this method, we identify 140 candidate binding proteins for lncRNA highly upregulated in liver cancer (HULC). Intriguingly, HULC ... [more]

Nat Commun Dec. 22, 2019; 11(1);3162 [Pubmed: 32572027]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
HULC LDHA
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
2881545
LDHA HULC
Affinity Capture-RNA
Affinity Capture-RNA

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Low-BioGRID
-
LDHA HULC
Protein-RNA
Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Low-BioGRID
-

Curated By

  • BioGRID