BAIT
ALOX12
12-LOX, 12S-LOX, LOG12
arachidonate 12-lipoxygenase
GO Process (23)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- arachidonic acid metabolic process [IDA, ISS, TAS]
- cellular component movement [IMP]
- establishment of skin barrier [ISS]
- fatty acid oxidation [IMP]
- hepoxilin biosynthetic process [ISS]
- hepoxilin metabolic process [TAS]
- leukotriene A4 metabolic process [IDA]
- linoleic acid metabolic process [IDA]
- lipoxin A4 biosynthetic process [IDA]
- lipoxin B4 biosynthetic process [IDA]
- lipoxin metabolic process [TAS]
- lipoxygenase pathway [IDA, TAS]
- negative regulation of apoptotic process [IMP, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of platelet aggregation [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP, ISS]
- reactive oxygen species metabolic process [NAS]
- small molecule metabolic process [TAS]
- superoxide anion generation [NAS]
Gene Ontology Molecular Function- arachidonate 12-lipoxygenase activity [IDA, TAS]
- hepoxilin A3 synthase activity [TAS]
- hepoxilin-epoxide hydrolase activity [ISS]
- linoleate 13S-lipoxygenase activity [IDA]
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [TAS]
- protein binding [IPI]
- arachidonate 12-lipoxygenase activity [IDA, TAS]
- hepoxilin A3 synthase activity [TAS]
- hepoxilin-epoxide hydrolase activity [ISS]
- linoleate 13S-lipoxygenase activity [IDA]
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [TAS]
- protein binding [IPI]
Homo sapiens
PREY
TRIB1
C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1
tribbles pseudokinase 1
GO Process (10)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- JNK cascade [IMP]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of protein kinase activity [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP, ISS]
- negative regulation of smooth muscle cell migration [IMP]
- negative regulation of smooth muscle cell proliferation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [TAS]
- regulation of MAP kinase activity [IDA]
- response to lipopolysaccharide [IMP, ISS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
The platelet isoform of 12-lipoxygenase (12-LOX) is expressed in a variety of human tumors. 12-LOX metabolizes arachidonic acid to 12(S)-hydroxyeicosateraenoic acid (12(S)-HETE), which induces a number of cellular responses associated with tumor progression and metastasis. Little is known about 12-LOX regulation and no direct regulators of 12-LOX activity have been identified. To identify potential regulators of 12-LOX, we isolated cDNAs ... [more]
Biochemistry Mar. 28, 2000; 39(12);3185-91 [Pubmed: 10727209]
Throughput
- Low Throughput
Curated By
- BioGRID