BAIT

RGS3

C2PA, RGP3, RP11-168K11.4

regulator of G-protein signaling 3

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

inactivation of MAPK activity [TAS]

positive regulation of GTPase activity [IBA, TAS]

regulation of G-protein coupled receptor protein signaling pathway [TAS]

Gene Ontology Molecular Function

GTPase activator activity [IBA]

Gene Ontology Cellular Component

cytoplasm [IBA, IDA]

nucleoplasm [IDA]

plasma membrane [IBA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

YWHAB

GW128, HEL-S-1, HS1, KCIP-1, YWHAA, RP1-148E22.1

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

GO Process (22)

GO Function (6)

GO Component (7)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

MAPK cascade [TAS]

RNA metabolic process [TAS]

Ras protein signal transduction [TAS]

activation of MAPKK activity [TAS]

apoptotic process [TAS]

axon guidance [TAS]

cytoplasmic sequestering of protein [IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

gene expression [TAS]

hippo signaling [TAS]

innate immune response [TAS]

insulin receptor signaling pathway [TAS]

intrinsic apoptotic signaling pathway [TAS]

mRNA metabolic process [TAS]

membrane organization [TAS]

negative regulation of protein dephosphorylation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

positive regulation of catalytic activity [IDA]

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]

small GTPase mediated signal transduction [TAS]

Gene Ontology Molecular Function

enzyme binding [IPI]
histone deacetylase binding [IPI]
phosphoprotein binding [IPI]
phosphoserine binding [IPI]
protein binding [IPI]
protein domain specific binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytoplasmic vesicle membrane [TAS]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

perinuclear region of cytoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity.

Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G

Regulator of G protein signaling (RGS) proteins function as GTPase-activating proteins (GAPs) that stimulate the inactivation of heterotrimeric G proteins. We have recently shown that RGS proteins may be regulated on a post-translational level (Benzing, T., Brandes, R., Sellin, L., Schermer, B., Lecker, S., Walz, G., and Kim, E. (1999) Nat. Med. 5, 913-918). However, mechanisms controlling the GAP activity ... [more]

J. Biol. Chem. Sep. 08, 2000; 275(36);28167-72 [Pubmed: 10862767]

Throughput

Low Throughput

Curated By

BioGRID