BAIT
MSN4
stress-responsive transcriptional activator MSN4, L000001199, YKL062W
Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift
GO Process (21)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- age-dependent response to oxidative stress involved in chronological cell aging [IGI]
- cellular response to acidic pH [IMP]
- chromatin remodeling [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to cold [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to ethanol [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to freezing [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [IGI]
- regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction [IGI]
- replicative cell aging [IGI]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
HOT1
L000004957, YMR172W
Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
GO Process (4)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- RNA polymerase II transcriptional preinitiation complex assembly [IDA, IMP]
- cellular hyperosmotic salinity response [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Hog1-induced transcription of RTC3 and HSP12 is robust and occurs in cells lacking Msn2, Msn4, Hot1 and Sko1.
The yeast MAP kinase Hog1 pathway activates transcription of several hundreds genes. Large-scale gene expression and DNA binding assays suggest that most Hog1-induced genes are regulated by the transcriptional activators Msn2/4, Hot1 and Sko1. These studies also revealed the target genes of each activator and the putative binding sites on their promoters. In a previous study we identified a group ... [more]
PLoS One Aug. 18, 2020; 15(8);e0237540 [Pubmed: 32804965]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide accumulation (APO:0000149)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOT1 MSN4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 520887 |
Curated By
- BioGRID