BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
DAB2IP
2310011D08Rik, AI480459, Aip1, mKIAA1743, RP23-4L24.1
disabled 2 interacting protein
GO Process (64)
GO Function (21)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IMP]
- activation of JUN kinase activity [ISO]
- activation of MAPKKK activity [ISO]
- cell motility involved in cerebral cortex radial glia guided migration [IMP]
- cellular protein catabolic process [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to interleukin-1 [IDA, ISO]
- cellular response to lipopolysaccharide [IDA, ISO]
- cellular response to tumor necrosis factor [IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- layer formation in cerebral cortex [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of G0 to G1 transition [ISO]
- negative regulation of GTPase activity [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Ras GTPase activity [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin catabolic process [ISO]
- negative regulation of endothelial cell migration [IMP, ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of phosphatidylinositol 3-kinase activity [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein phosphorylation [IMP, ISO]
- negative regulation of protein serine/threonine kinase activity [IMP, ISO]
- negative regulation of toll-like receptor 4 signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- neuron projection morphogenesis [IMP]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [IMP, ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras GTPase activity [IBA, ISO]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of dendrite development [IMP]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein catabolic process [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP, ISO]
- positive regulation of synapse maturation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of ARF GTPase activity [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of p38MAPK cascade [IMP]
- regulation of protein complex assembly [IMP, ISO]
- tube formation [IMP, ISO]
- vascular endothelial growth factor receptor-2 signaling pathway [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- axon [IDA]
- cerebellar mossy fiber [IDA]
- climbing fiber [IDA]
- cytoplasm [IBA, IDA, ISO]
- endocytic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [IDA]
- neuronal cell body membrane [IDA]
- parallel fiber [IDA]
- plasma membrane [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID