BAIT
EPHA3
EK4, ETK, ETK1, HEK, HEK4, TYRO4
EPH receptor A3
GO Process (11)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cell migration [ISS]
- cellular response to retinoic acid [IMP]
- ephrin receptor signaling pathway [IDA]
- fasciculation of motor neuron axon [ISS]
- fasciculation of sensory neuron axon [ISS]
- positive regulation of neuron projection development [IMP]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of epithelial to mesenchymal transition [ISS]
- regulation of focal adhesion assembly [IDA]
- regulation of microtubule cytoskeleton organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Presenilin/?-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA.
EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/?-secretase is required for axon growth in the developing mouse brain. PS1/?-secretase mediates axon growth by inhibiting RhoA signaling and cleaving EphA3 independently of ligand to generate an intracellular domain (ICD) fragment that reverses axon defects ... [more]
Elife Dec. 02, 2018; 8(); [Pubmed: 31577226]
Throughput
- Low Throughput
Curated By
- BioGRID