BAIT
EPHA3
EK4, ETK, ETK1, HEK, HEK4, TYRO4
EPH receptor A3
GO Process (11)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cell migration [ISS]
- cellular response to retinoic acid [IMP]
- ephrin receptor signaling pathway [IDA]
- fasciculation of motor neuron axon [ISS]
- fasciculation of sensory neuron axon [ISS]
- positive regulation of neuron projection development [IMP]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of epithelial to mesenchymal transition [ISS]
- regulation of focal adhesion assembly [IDA]
- regulation of microtubule cytoskeleton organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CLTC
CHC, CHC17, CLH-17, CLTCL2, Hc
clathrin, heavy chain (Hc)
GO Process (11)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- intracellular protein transport [NAS]
- membrane organization [TAS]
- mitotic nuclear division [IMP]
- negative regulation of hyaluronan biosynthetic process [IDA, IMP]
- negative regulation of protein localization to plasma membrane [IMP]
- osteoblast differentiation [IDA]
- post-Golgi vesicle-mediated transport [TAS]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IMP]
- transferrin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- clathrin coat [NAS]
- clathrin complex [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- clathrin-coated vesicle [IDA]
- cytoplasm [IDA]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- plasma membrane [TAS]
- protein complex [IDA]
- spindle [IDA]
- trans-Golgi network membrane [TAS]
- vesicle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Presenilin/?-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA.
EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/?-secretase is required for axon growth in the developing mouse brain. PS1/?-secretase mediates axon growth by inhibiting RhoA signaling and cleaving EphA3 independently of ligand to generate an intracellular domain (ICD) fragment that reverses axon defects ... [more]
Elife Dec. 02, 2018; 8(); [Pubmed: 31577226]
Throughput
- Low Throughput
Curated By
- BioGRID