BAIT
UCHL1
HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
GO Process (3)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLA2G4B
HsT16992, cPLA2-beta
phospholipase A2, group IVB (cytosolic)
GO Process (16)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- arachidonic acid metabolic process [NAS]
- calcium-mediated signaling [NAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- glycerophospholipid biosynthetic process [TAS]
- glycerophospholipid catabolic process [IDA]
- inflammatory response [NAS]
- parturition [NAS]
- phosphatidic acid biosynthetic process [TAS]
- phosphatidylcholine acyl-chain remodeling [TAS]
- phosphatidylethanolamine acyl-chain remodeling [TAS]
- phosphatidylglycerol acyl-chain remodeling [TAS]
- phosphatidylserine acyl-chain remodeling [TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC. Restoration of UCHL1 inhibited the migration and invasion of NPC cells in vitro and in vivo, and knockdown of UCHL1 ... [more]
Cells Dec. 27, 2019; 9(3); [Pubmed: 32120844]
Throughput
- High Throughput
Curated By
- BioGRID