HRQ1
Gene Ontology Biological Process
Gene Ontology Molecular Function
MRE11
Gene Ontology Biological Process
- DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [IMP]
- DNA repair [IMP]
- ascospore formation [IMP]
- base-excision repair [IMP]
- double-strand break repair via break-induced replication [IGI, IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA double-strand break processing [TAS]
- mitochondrial double-strand break repair via homologous recombination [IMP]
- reciprocal meiotic recombination [IMP]
- regulation of transcription during meiosis [IMP]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IDA]
- G-quadruplex DNA binding [IDA]
- adenylate kinase activity [IDA]
- double-stranded telomeric DNA binding [IDA]
- endodeoxyribonuclease activity [IDA]
- endonuclease activity [IDA]
- protein complex scaffold [IGI, IMP]
- single-stranded telomeric DNA binding [IDA]
- telomeric DNA binding [IDA]
- 3'-5' exonuclease activity [IDA]
- G-quadruplex DNA binding [IDA]
- adenylate kinase activity [IDA]
- double-stranded telomeric DNA binding [IDA]
- endodeoxyribonuclease activity [IDA]
- endonuclease activity [IDA]
- protein complex scaffold [IGI, IMP]
- single-stranded telomeric DNA binding [IDA]
- telomeric DNA binding [IDA]
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1.
Most eukaryotic genomes encode multiple RecQ family helicases, including five such enzymes in humans. For many years, the yeast Saccharomyces cerevisiae was considered unusual in that it only contained a single RecQ helicase, named Sgs1 However, it has recently been discovered that a second RecQ helicase, called Hrq1, resides in yeast. Both Hrq1 and Sgs1 are involved in genome integrity, ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- SGA with hrq1-K318A sgs1-K706A double mutant as query against temperature-sensitive collection, see Table S17 for ts allele (hit); genetic complex
- SGA with hrq1-K318A sgs1-deletion double mutant as query against temperature-sensitive collection, see Table S16 for ts allele (hit); genetic complex
- SGA with hrq1-deletion sgs1-K706A double mutant as query against temperature-sensitive collection, see Table S15 for ts allele (hit); genetic complex
- SGA with hrq1-deletion sgs1-deletion double mutant as query against temperature-sensitive collection, see Table S14 for ts allele (hit); genetic complex
- SGA with hrq1-deletion sgs1-deletion double mutant as query; genetic complex
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HRQ1 MRE11 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 938193 |
Curated By
- BioGRID