SGS1
Gene Ontology Biological Process
- DNA double-strand break processing [IGI]
- DNA duplex unwinding [IDA]
- DNA topological change [IDA]
- DNA unwinding involved in DNA replication [IDA]
- cellular response to DNA damage stimulus [IMP]
- chromosome organization [IMP]
- double-strand break repair via homologous recombination [IGI, IMP]
- gene conversion at mating-type locus, DNA double-strand break processing [IGI]
- intra-S DNA damage checkpoint [IGI, IMP]
- meiotic DNA double-strand break processing [IGI]
- meiotic chromosome segregation [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of meiotic joint molecule formation [IGI]
- regulation of reciprocal meiotic recombination [IGI]
- replicative cell aging [IMP]
- telomere maintenance [IGI]
- telomere maintenance via recombination [IGI, IMP]
- telomeric 3' overhang formation [IGI]
Gene Ontology Molecular Function
CDC13
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1.
Most eukaryotic genomes encode multiple RecQ family helicases, including five such enzymes in humans. For many years, the yeast Saccharomyces cerevisiae was considered unusual in that it only contained a single RecQ helicase, named Sgs1 However, it has recently been discovered that a second RecQ helicase, called Hrq1, resides in yeast. Both Hrq1 and Sgs1 are involved in genome integrity, ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- SGA with hrq1-K318A sgs1-K706A double mutant as query against temperature-sensitive collection, see Table S17 for ts allele (hit); genetic complex
- SGA with hrq1-K318A sgs1-deletion double mutant as query against temperature-sensitive collection, see Table S16 for ts allele (hit); genetic complex
- SGA with hrq1-deletion sgs1-K706A double mutant as query against temperature-sensitive collection, see Table S15 for ts allele (hit); genetic complex
- SGA with sgs1-K706A as query against temperature-sensitive collection, see Table S13 for ts allele (hit)
- SGA with sgs1-deletion as query against temperature-sensitive collection, see Table S12 for ts allele (hit)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC13 SGS1 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 448915 | |
| SGS1 CDC13 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | High | - | BioGRID | 2340589 | |
| SGS1 CDC13 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 519398 | |
| CDC13 SGS1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 513125 | |
| CDC13 SGS1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 519399 |
Curated By
- BioGRID