BAIT
UNC5B
UNC5H2, p53RDL1, RP11-58O1.1
unc-5 homolog B (C. elegans)
GO Process (7)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- apoptotic process [TAS]
- axon guidance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of neuron apoptotic process [IMP]
- positive regulation of apoptotic process [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
FLRT3
HH21, UNQ856/PRO1865
fibronectin leucine rich transmembrane protein 3
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons.
Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A-Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of Netrin-1, suggesting the presence of other ligands. Unc5B was recently shown to bind fibronectin and leucine-rich transmembrane protein-3 (FLRT3), although the relevance of this interaction for nervous system development remained ... [more]
EMBO J Jun. 14, 2011; 30(14);2920-33 [Pubmed: 21673655]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLRT3 UNC5B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID