KCNQ1
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [IMP]
- cellular response to cAMP [IDA, IMP]
- cellular response to drug [IDA]
- cellular response to epinephrine stimulus [TAS]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IMP, TAS]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion transmembrane transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of heart contraction [IC]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IDA, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sensory perception of sound [TAS]
- synaptic transmission [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calmodulin binding [IDA]
- delayed rectifier potassium channel activity [IDA]
- ion channel binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- protein phosphatase 1 binding [IDA]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- calmodulin binding [IDA]
- delayed rectifier potassium channel activity [IDA]
- ion channel binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- protein phosphatase 1 binding [IDA]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
NEDD4L
Gene Ontology Biological Process
- cellular sodium ion homeostasis [NAS]
- excretion [NAS]
- gene expression [TAS]
- ion transmembrane transport [TAS]
- negative regulation of potassium ion transmembrane transport [IDA]
- negative regulation of potassium ion transmembrane transporter activity [IDA]
- negative regulation of protein localization to cell surface [IDA]
- negative regulation of sodium ion transmembrane transport [IDA]
- negative regulation of sodium ion transmembrane transporter activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of caveolin-mediated endocytosis [ISS]
- positive regulation of endocytosis [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K48-linked ubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IDA]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane depolarization [IDA]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- regulation of protein catabolic process [NAS]
- response to metal ion [IDA]
- sodium ion transport [NAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- transmembrane transport [TAS]
- ventricular cardiac muscle cell action potential [ISS]
- viral life cycle [TAS]
- viral process [TAS]
- water homeostasis [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes.
In long QT syndrome (LQTS) patients, modifier genes modulate the arrhythmic risk associated with a disease-causing mutation. Their recognition can improve risk stratification and clinical management, but their discovery represents a challenge. We tested whether a cellular-driven approach could help to identify new modifier genes and especially their mechanism of action.We generated human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) from two ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNQ1 NEDD4L | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KCNQ1 NEDD4L | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID