An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors.

Aguinaga D, Medrano M, Cordomi A, Jimenez-Roses M, Angelats E, Casanovas M, Vega-Quiroga I, Canela EI, Petrovic M, Gysling K, Pardo L, Franco R, Navarro G

Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (?1R) mediates cocaine anorectic effects by interacting in neurons with growth/hormone/secretagogue (ghrelin) receptors. Cocaine increases colocalization of ?1R and GHS-R1a at the cell ... [more]

Mol Neurobiol Feb. 01, 2019; 56(2);1196-1210 [Pubmed: 29876881]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

GHSR

Gene Ontology Biological Process

Gene Ontology Molecular Function

G-protein coupled receptor activity [IDA]growth hormone secretagogue receptor activity [IDA]growth hormone-releasing hormone receptor activity [IDA]

Gene Ontology Cellular Component

SIGMAR1