BAIT
USP1
RP23-329P19.1
ubiquitin specific peptidase 1
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- monoubiquitinated protein deubiquitination [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA, ISO]
- proteolysis [ISO]
- regulation of DNA repair [IBA, ISO]
- regulation of proteasomal protein catabolic process [IBA]
- response to UV [ISO]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
AQP4
WCH4
aquaporin 4
GO Process (10)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- carbohydrate transmembrane transport [IBA]
- cellular response to stress [IBA]
- cellular water homeostasis [IBA]
- glycerol transport [IBA]
- ion transmembrane transport [IBA]
- renal water absorption [IGI, IMP]
- sensory perception of sound [IMP]
- transmembrane transport [IDA]
- water homeostasis [IMP, NAS]
- water transport [IDA, IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
PI3K-Akt-FoxO-mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K-Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63-linked polyubiquitin chains on Akt to restrict PI3K-Akt-FoxO signaling in mouse muscle during prolonged starvation. DUB screening platform identified USP1 as a ... [more]
EMBO Rep Dec. 03, 2019; 21(4);e48791 [Pubmed: 32133736]
Throughput
- High Throughput
Curated By
- BioGRID