BAIT
WDR48
8430408H12Rik, Uaf1, mKIAA1449
WD repeat domain 48
GO Process (14)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IMP]
- embryonic organ development [IMP]
- homeostasis of number of cells [IMP]
- male gonad development [IMP]
- multicellular organism growth [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- protein deubiquitination [ISO]
- regulation of protein monoubiquitination [IMP]
- seminiferous tubule development [IMP]
- single fertilization [IMP]
- skeletal system morphogenesis [IMP]
- skin development [IMP]
- spermatogenesis [IMP]
Gene Ontology Cellular Component
Mus musculus
PREY
DAB2
5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, Doc-2, Doc2, p96, mCG_144967
disabled 2, mitogen-responsive phosphoprotein
GO Process (43)
GO Function (10)
GO Component (14)
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- cell morphogenesis involved in differentiation [IMP]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [IDA]
- clathrin coat assembly [IDA, ISO]
- endoderm development [IMP]
- excretion [IMP]
- in utero embryonic development [IMP]
- leading edge cell differentiation [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein localization to plasma membrane [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- pinocytosis [IMP]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [ISO]
- positive regulation of aldosterone biosynthetic process [ISO]
- positive regulation of aldosterone secretion [ISO]
- positive regulation of cell adhesion [IDA, IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of clathrin-mediated endocytosis [IDA, ISO]
- positive regulation of early endosome to late endosome transport [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP, ISO]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of receptor recycling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, IPI, ISO]
- regulation of Rho-dependent protein serine/threonine kinase activity [ISO]
- response to steroid hormone [ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- SMAD binding [ISO]
- cargo receptor activity [IDA, ISO]
- clathrin adaptor activity [IDA, ISO]
- clathrin binding [IDA]
- integrin binding [IMP]
- phosphatidylinositol binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- AP-2 adaptor complex binding [IDA]
- SMAD binding [ISO]
- cargo receptor activity [IDA, ISO]
- clathrin adaptor activity [IDA, ISO]
- clathrin binding [IDA]
- integrin binding [IMP]
- phosphatidylinositol binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- clathrin coat of coated pit [IDA]
- clathrin-coated vesicle [ISO]
- clathrin-coated vesicle membrane [ISO]
- coated pit [ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- nucleolus [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- transforming growth factor beta receptor homodimeric complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
PI3K-Akt-FoxO-mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K-Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63-linked polyubiquitin chains on Akt to restrict PI3K-Akt-FoxO signaling in mouse muscle during prolonged starvation. DUB screening platform identified USP1 as a ... [more]
EMBO Rep Dec. 03, 2019; 21(4);e48791 [Pubmed: 32133736]
Throughput
- High Throughput
Curated By
- BioGRID