BAIT
WDR48
8430408H12Rik, Uaf1, mKIAA1449
WD repeat domain 48
GO Process (14)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IMP]
- embryonic organ development [IMP]
- homeostasis of number of cells [IMP]
- male gonad development [IMP]
- multicellular organism growth [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- protein deubiquitination [ISO]
- regulation of protein monoubiquitination [IMP]
- seminiferous tubule development [IMP]
- single fertilization [IMP]
- skeletal system morphogenesis [IMP]
- skin development [IMP]
- spermatogenesis [IMP]
Gene Ontology Cellular Component
Mus musculus
PREY
ARID1A
1110030E03Rik, BAF250a, Osa1, Smarcf1, RP23-463N9.3
AT rich interactive domain 1A (SWI-like)
GO Process (17)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- androgen receptor signaling pathway [ISO]
- cardiac chamber development [IMP]
- cardiac muscle cell differentiation [IMP]
- chromatin organization [IPI]
- chromatin remodeling [ISO]
- forebrain development [IMP]
- glucocorticoid receptor signaling pathway [ISO]
- intracellular estrogen receptor signaling pathway [ISO]
- maintenance of chromatin silencing [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neural tube closure [IMP]
- nucleosome disassembly [ISO]
- optic cup formation involved in camera-type eye development [IMP]
- placenta blood vessel development [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
PI3K-Akt-FoxO-mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K-Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63-linked polyubiquitin chains on Akt to restrict PI3K-Akt-FoxO signaling in mouse muscle during prolonged starvation. DUB screening platform identified USP1 as a ... [more]
EMBO Rep Dec. 03, 2019; 21(4);e48791 [Pubmed: 32133736]
Throughput
- High Throughput
Curated By
- BioGRID