BAIT
FOXO3
1110048B16Rik, 2010203A17Rik, C76856, FKHRL1, Fkhr2, Foxo3a
forkhead box O3
GO Process (19)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IDA]
- antral ovarian follicle growth [IMP]
- cellular response to oxidative stress [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- glucose homeostasis [IMP]
- initiation of primordial ovarian follicle growth [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neuronal stem cell maintenance [IGI]
- oocyte maturation [IMP]
- ovulation from ovarian follicle [IMP]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of neural precursor cell proliferation [IGI]
- regulation of reactive oxygen species metabolic process [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IGI]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IGI]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
Mus musculus
PREY
ETL4
6620402G01Rik, 9430077C05Rik, BC026657, E330027G05Rik, Etl-4, Skt, RP23-436G18.1
enhancer trap locus 4
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
PI3K-Akt-FoxO-mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K-Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63-linked polyubiquitin chains on Akt to restrict PI3K-Akt-FoxO signaling in mouse muscle during prolonged starvation. DUB screening platform identified USP1 as a ... [more]
EMBO Rep Dec. 03, 2019; 21(4);e48791 [Pubmed: 32133736]
Throughput
- High Throughput
Curated By
- BioGRID