HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOA1
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA, IMP]
- cholesterol import [IMP]
- cholesterol metabolic process [IMP]
- cholesterol transport [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IC]
- high-density lipoprotein particle remodeling [IC]
- integrin-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- negative chemotaxis [IDA]
- negative regulation of cell adhesion molecule production [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta secretion [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- negative regulation of very-low-density lipoprotein particle remodeling [IDA]
- peptidyl-methionine modification [IDA]
- phosphatidylcholine biosynthetic process [IDA]
- phospholipid efflux [IDA]
- phospholipid homeostasis [IDA]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of hydrolase activity [IDA]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- protein oxidation [IDA]
- protein stabilization [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [IDA]
- transmembrane transport [TAS]
- triglyceride homeostasis [IDA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endocytic vesicle [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [TAS]
- extracellular space [IDA, ISS]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- plasma membrane [TAS]
- secretory granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Extracellular Hsp90? and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.
Extracellular heat shock protein 90 alpha (eHsp90?, also known as HSP90AA1) has been widely reported to promote tumor cell motility and tumor metastasis in various types of cancer. Several extracellular proteins and membrane receptors have been identified as interacting proteins of eHsp90? and mediate its pro-metastasis function. However, the regulatory mechanism of eHsp90? activity remains largely unknown. Here, we report ... [more]
Throughput
- High Throughput
Curated By
- BioGRID