HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOA4
Gene Ontology Biological Process
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- chylomicron assembly [TAS]
- chylomicron remodeling [IC]
- high-density lipoprotein particle remodeling [IC]
- hydrogen peroxide catabolic process [IDA]
- innate immune response in mucosa [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipid homeostasis [IDA]
- lipid transport [IDA]
- lipoprotein metabolic process [TAS]
- multicellular organismal lipid catabolic process [IDA]
- negative regulation of plasma lipoprotein particle oxidation [IDA]
- phosphatidylcholine metabolic process [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of fatty acid biosynthetic process [IDA]
- positive regulation of lipoprotein lipase activity [IDA]
- positive regulation of triglyceride catabolic process [IDA]
- protein-lipid complex assembly [IMP]
- regulation of cholesterol transport [IDA]
- removal of superoxide radicals [IDA]
- response to lipid hydroperoxide [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- very-low-density lipoprotein particle remodeling [IDA]
Gene Ontology Molecular Function- antioxidant activity [IDA]
- cholesterol transporter activity [IDA]
- copper ion binding [IDA]
- lipid binding [IMP]
- lipid transporter activity [TAS]
- phosphatidylcholine binding [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- antioxidant activity [IDA]
- cholesterol transporter activity [IDA]
- copper ion binding [IDA]
- lipid binding [IMP]
- lipid transporter activity [TAS]
- phosphatidylcholine binding [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- chylomicron [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [NAS, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Extracellular Hsp90? and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.
Extracellular heat shock protein 90 alpha (eHsp90?, also known as HSP90AA1) has been widely reported to promote tumor cell motility and tumor metastasis in various types of cancer. Several extracellular proteins and membrane receptors have been identified as interacting proteins of eHsp90? and mediate its pro-metastasis function. However, the regulatory mechanism of eHsp90? activity remains largely unknown. Here, we report ... [more]
Throughput
- High Throughput
Curated By
- BioGRID