BAIT
PTK2
FAK, FRNK, p125FAK
protein tyrosine kinase 2
GO Process (58)
GO Function (11)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [IMP]
- MAPK cascade [IMP]
- angiogenesis [IBA, ISO]
- blood vessel development [ISO]
- cellular chloride ion homeostasis [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system neuron axonogenesis [ISO]
- cytoskeleton organization [IBA]
- endothelial cell migration [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [ISO]
- extracellular matrix organization [ISO]
- fat cell differentiation [IEP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- microtubule cytoskeleton organization [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [ISO]
- negative regulation of synapse assembly [ISO]
- neuron migration [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO, ISS]
- positive regulation of protein kinase B signaling [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of synaptic transmission [IMP]
- positive regulation of vasodilation [IMP]
- protein autophosphorylation [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO, ISS]
- regulation of cell proliferation [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of osteoblast differentiation [ISO, ISS]
- response to arsenic-containing substance [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucose [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [IDA]
- cytoplasm [ISO]
- cytosol [ISO, ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO, TAS]
- intercalated disc [IDA]
- lamellipodium [ISO]
- nuclear body [IDA]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [IDA]
- stress fiber [ISO]
Rattus norvegicus
PREY
PTK2
FAK, FRNK, p125FAK
protein tyrosine kinase 2
GO Process (58)
GO Function (11)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [IMP]
- MAPK cascade [IMP]
- angiogenesis [IBA, ISO]
- blood vessel development [ISO]
- cellular chloride ion homeostasis [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system neuron axonogenesis [ISO]
- cytoskeleton organization [IBA]
- endothelial cell migration [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [ISO]
- extracellular matrix organization [ISO]
- fat cell differentiation [IEP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- microtubule cytoskeleton organization [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [ISO]
- negative regulation of synapse assembly [ISO]
- neuron migration [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO, ISS]
- positive regulation of protein kinase B signaling [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of synaptic transmission [IMP]
- positive regulation of vasodilation [IMP]
- protein autophosphorylation [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO, ISS]
- regulation of cell proliferation [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of osteoblast differentiation [ISO, ISS]
- response to arsenic-containing substance [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucose [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [IPI]
- integrin binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO, TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [IDA]
- cytoplasm [ISO]
- cytosol [ISO, ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO, TAS]
- intercalated disc [IDA]
- lamellipodium [ISO]
- nuclear body [IDA]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [IDA]
- stress fiber [ISO]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.
A second protein-tyrosine kinase (PTK) of the focal adhesion kinase (FAK) subfamily, cell adhesion kinase beta (CAK beta), was identified by cDNA cloning. The rat CAK beta is a 115.7-kDa PTK that contains N- and C-terminal domains of 418 and 330 amino acid residues besides the central kinase domain. The rat CAK beta has a homology with mouse FAK over ... [more]
J Biol Chem Sep. 08, 1995; 270(36);21206-19 [Pubmed: 7673154]
Throughput
- Low Throughput
Curated By
- BioGRID