BAIT
PTK2B
CAKB, CAKbeta, Pyk2
protein tyrosine kinase 2 beta
GO Process (88)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- actin filament organization [IMP]
- activation of Janus kinase activity [IMP, ISO]
- activation of Rac GTPase activity [IMP]
- angiogenesis [IMP]
- blood vessel endothelial cell migration [IMP]
- bone resorption [ISO, ISS]
- cell adhesion [IMP]
- cell differentiation [IEP]
- cell surface receptor signaling pathway [ISO, ISS]
- cellular defense response [IMP]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IMP]
- focal adhesion assembly [IMP]
- glial cell proliferation [IEP]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IMP]
- long-term synaptic potentiation [IMP]
- marginal zone B cell differentiation [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of bone mineralization [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of ossification [IMP]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [IMP]
- oocyte maturation [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell chemotaxis [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [IEP, ISO]
- positive regulation of cell-matrix adhesion [ISO, ISS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of actin cytoskeleton reorganization [ISO, ISS]
- regulation of cGMP biosynthetic process [ISO]
- regulation of cGMP-mediated signaling [ISO]
- regulation of calcium-mediated signaling [ISO]
- regulation of cell adhesion [IBA, ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of establishment of cell polarity [ISO, ISS]
- regulation of inositol trisphosphate biosynthetic process [ISO, ISS]
- regulation of macrophage chemotaxis [ISO, ISS]
- regulation of nitric oxide biosynthetic process [ISO]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO, ISS]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hormone [IEP]
- response to hydrogen peroxide [IPI]
- response to hypoxia [IEP]
- response to immobilization stress [IEP]
- response to lithium ion [IEP]
- response to mechanical stimulus [IEP]
- response to organonitrogen compound [IEP]
- response to osmotic stress [IEP]
- response to reactive oxygen species [IEP]
- sprouting angiogenesis [ISO, ISS]
- stress fiber assembly [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, IMP]
- apical dendrite [IDA]
- axon [IDA]
- cell body [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- dendrite [IDA]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- growth cone [IDA]
- lamellipodium [ISO, ISS]
- membrane raft [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
PREY
PTK2B
CAKB, CAKbeta, Pyk2
protein tyrosine kinase 2 beta
GO Process (88)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- actin filament organization [IMP]
- activation of Janus kinase activity [IMP, ISO]
- activation of Rac GTPase activity [IMP]
- angiogenesis [IMP]
- blood vessel endothelial cell migration [IMP]
- bone resorption [ISO, ISS]
- cell adhesion [IMP]
- cell differentiation [IEP]
- cell surface receptor signaling pathway [ISO, ISS]
- cellular defense response [IMP]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [IMP]
- focal adhesion assembly [IMP]
- glial cell proliferation [IEP]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IMP]
- long-term synaptic potentiation [IMP]
- marginal zone B cell differentiation [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of bone mineralization [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of ossification [IMP]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [IMP]
- oocyte maturation [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, IMP]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell chemotaxis [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of cell proliferation [IEP, ISO]
- positive regulation of cell-matrix adhesion [ISO, ISS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- positive regulation of protein kinase activity [ISO, ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of actin cytoskeleton reorganization [ISO, ISS]
- regulation of cGMP biosynthetic process [ISO]
- regulation of cGMP-mediated signaling [ISO]
- regulation of calcium-mediated signaling [ISO]
- regulation of cell adhesion [IBA, ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of establishment of cell polarity [ISO, ISS]
- regulation of inositol trisphosphate biosynthetic process [ISO, ISS]
- regulation of macrophage chemotaxis [ISO, ISS]
- regulation of nitric oxide biosynthetic process [ISO]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO, ISS]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hormone [IEP]
- response to hydrogen peroxide [IPI]
- response to hypoxia [IEP]
- response to immobilization stress [IEP]
- response to lithium ion [IEP]
- response to mechanical stimulus [IEP]
- response to organonitrogen compound [IEP]
- response to osmotic stress [IEP]
- response to reactive oxygen species [IEP]
- sprouting angiogenesis [ISO, ISS]
- stress fiber assembly [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [IDA]
- N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- calmodulin-dependent protein kinase activity [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [ISO]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, IMP]
- apical dendrite [IDA]
- axon [IDA]
- cell body [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- dendrite [IDA]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- growth cone [IDA]
- lamellipodium [ISO, ISS]
- membrane raft [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.
A second protein-tyrosine kinase (PTK) of the focal adhesion kinase (FAK) subfamily, cell adhesion kinase beta (CAK beta), was identified by cDNA cloning. The rat CAK beta is a 115.7-kDa PTK that contains N- and C-terminal domains of 418 and 330 amino acid residues besides the central kinase domain. The rat CAK beta has a homology with mouse FAK over ... [more]
J Biol Chem Sep. 08, 1995; 270(36);21206-19 [Pubmed: 7673154]
Throughput
- Low Throughput
Curated By
- BioGRID