ITGAV
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- T cell activation [TAS]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- apoptotic cell clearance [IMP]
- blood vessel development [IMP]
- calcium ion transmembrane transport [ISO]
- cell adhesion [ISO]
- cell growth [ISO]
- cell migration [ISO]
- cell-matrix adhesion [ISO, TAS]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [ISO]
- detection of molecule of bacterial origin [TAS]
- endodermal cell differentiation [ISO]
- endothelial cell migration [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- fertilization [NAS]
- focal adhesion assembly [NAS]
- gonad morphogenesis [NAS]
- heterotypic cell-cell adhesion [ISO]
- inflammatory response [TAS]
- integrin-mediated signaling pathway [ISO]
- negative chemotaxis [ISO]
- negative regulation of entry of bacterium into host cell [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of lipoprotein metabolic process [ISO]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of osteoblast proliferation [IMP]
- regulation of apoptotic cell clearance [IDA]
- regulation of bone resorption [TAS]
- regulation of ion transmembrane transport [ISO]
- regulation of phagocytosis [ISO, NAS]
- release of sequestered calcium ion into cytosol [TAS]
- response to nitric oxide [TAS]
- substrate adhesion-dependent cell spreading [ISO]
- trophoblast giant cell differentiation [TAS]
- viral entry into host cell [ISO]
Gene Ontology Molecular Function- extracellular matrix binding [ISO]
- extracellular matrix protein binding [ISO]
- fibronectin binding [ISO]
- insulin-like growth factor I binding [ISO]
- opsonin binding [IDA]
- peptide binding [ISO]
- protease binding [ISO]
- protein heterodimerization activity [TAS]
- protein kinase C binding [IDA]
- receptor binding [ISO]
- voltage-gated calcium channel activity [ISO]
- extracellular matrix binding [ISO]
- extracellular matrix protein binding [ISO]
- fibronectin binding [ISO]
- insulin-like growth factor I binding [ISO]
- opsonin binding [IDA]
- peptide binding [ISO]
- protease binding [ISO]
- protein heterodimerization activity [TAS]
- protein kinase C binding [IDA]
- receptor binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- alphav-beta3 integrin-IGF-1-IGF1R complex [ISO]
- cell surface [ISO]
- cytosol [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- integrin alphav-beta3 complex [ISO, TAS]
- integrin alphav-beta5 complex [ISO]
- integrin alphav-beta8 complex [ISO]
- integrin complex [ISO]
- intracellular [IDA]
- lamellipodium membrane [ISO]
- membrane [IDA]
- microvillus membrane [ISO]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
- ruffle membrane [ISO]
RTN4
Gene Ontology Biological Process
- angiogenesis [IMP]
- axonal fasciculation [IMP, ISO]
- cardiac epithelial to mesenchymal transition [IMP]
- cerebral cortex radial glia guided migration [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IMP, ISO, ISS]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of neuron projection regeneration [ISO]
- nervous system development [IDA]
- positive regulation of dopamine secretion [ISO]
- positive regulation of glial cell differentiation [ISO]
- regulation of axon regeneration [ISO]
- regulation of branching morphogenesis of a nerve [IMP, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [IMP]
- regulation of sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [IDA]
- cytoplasm [ISO]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [ISO, ISS]
- intracellular [ISO]
- myelin sheath [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [ISO, ISS]
- plasma membrane [ISO]
- protein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism.
Myelin-derived Nogo-A protein limits axonal growth after CNS injury. One domain binds to the Nogo-66 receptor to inhibit axonal outgrowth, whereas a second domain, Amino-Nogo, inhibits axonal outgrowth and cell adhesion through unknown mechanisms. Here, we show that Amino-Nogo inhibition depends strictly on the composition of the extracellular matrix, suggesting that Amino-Nogo inhibits the function of certain integrins. Amino-Nogo inhibition ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID