BAIT
RNF4
SLX5, SNURF, RES4-26
ring finger protein 4
GO Process (12)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K11-linked ubiquitination [ISS]
- protein K48-linked ubiquitination [ISS]
- protein K6-linked ubiquitination [ISS]
- protein K63-linked ubiquitination [ISS]
- protein autoubiquitination [ISS]
- regulation of kinetochore assembly [IMP]
- regulation of spindle assembly [IMP]
- response to arsenic-containing substance [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
ACSL4
ACS4, FACL4, LACS4, MRX63, MRX68
acyl-CoA synthetase long-chain family member 4
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- lipid biosynthetic process [IDA]
- lipid metabolic process [IDA]
- long-chain fatty acid metabolic process [IDA]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- negative regulation of prostaglandin secretion [IDA]
- positive regulation of cell growth [IDA]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.
Exposure of cells to heat or oxidative stress causes misfolding of proteins. To avoid toxic protein aggregation, cells have evolved nuclear and cytosolic protein quality control (PQC) systems. In response to proteotoxic stress, cells also limit protein synthesis by triggering transient storage of mRNAs and RNA-binding proteins (RBPs) in cytosolic stress granules (SGs). We demonstrate that the SUMO-targeted ubiquitin ligase ... [more]
Mol Cell Dec. 02, 2019; 79(1);54-67.e7 [Pubmed: 32521226]
Throughput
- High Throughput
Curated By
- BioGRID