BAIT
DDX58
RIG-I, RIGI, RLR-1, RP11-334P12.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- RIG-I signaling pathway [IMP]
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell migration [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CYP1B1
CP1B, CYPIB1, GLC3A, P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1
GO Process (32)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- arachidonic acid metabolic process [IDA, TAS]
- blood vessel morphogenesis [ISS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [ISS]
- cellular response to organic cyclic compound [IDA]
- collagen fibril organization [ISS]
- endothelial cell migration [ISS]
- epoxygenase P450 pathway [TAS]
- estrogen metabolic process [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISS]
- membrane lipid catabolic process [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell adhesion mediated by integrin [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- nitric oxide biosynthetic process [ISS]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [TAS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of reactive oxygen species metabolic process [ISS]
- retinal blood vessel morphogenesis [ISS]
- retinal metabolic process [IDA]
- retinol metabolic process [IDA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IDA]
- sterol metabolic process [TAS]
- trabecular meshwork development [ISS]
- visual perception [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.
Retinoic acid-inducible gene I (RIG-I) is up-regulated during granulocytic differentiation of acute promyelocytic leukemia (APL) cells induced by all-trans retinoic acid (ATRA). It has been reported that RIG-I recognizes virus-specific 5'-ppp-double-stranded RNA (dsRNA) and activates the type I interferons signaling pathways in innate immunity. However, the functions of RIG-I in hematopoiesis remain unclear, especially regarding its possible interaction with endogenous ... [more]
Proc Natl Acad Sci U S A Dec. 23, 2019; 117(25);14395-14404 [Pubmed: 32513696]
Throughput
- High Throughput
Curated By
- BioGRID