BAIT
IL1B
IL-1, IL1-BETA, IL1F2
interleukin 1, beta
GO Process (60)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPK activity [IDA]
- apoptotic process [TAS]
- cell-cell signaling [TAS]
- cellular response to drug [IDA]
- cellular response to mechanical stimulus [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to organic substance [IDA]
- cytokine-mediated signaling pathway [IDA]
- embryo implantation [TAS]
- hyaluronan biosynthetic process [IDA]
- inflammatory response [IDA, NAS]
- lipopolysaccharide-mediated signaling pathway [IDA]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of adiponectin secretion [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of lipid metabolic process [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- positive regulation of JNK cascade [IBA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell mediated immunity [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of angiogenesis [ISS]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of cell adhesion molecule production [NAS]
- positive regulation of fever generation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA, NAS]
- positive regulation of histone acetylation [NAS]
- positive regulation of histone phosphorylation [NAS]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-6 production [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of lipid catabolic process [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myosin light chain kinase activity [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of prostaglandin secretion [ISS]
- positive regulation of protein export from nucleus [NAS]
- positive regulation of protein phosphorylation [IDA, NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, ISS]
- protein kinase B signaling [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of insulin secretion [IDA]
- sequestering of triglyceride [IDA]
- signal transduction [TAS]
- smooth muscle adaptation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHMP4B
C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4
charged multivesicular body protein 4B
GO Process (12)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- endosomal transport [TAS]
- membrane organization [TAS]
- negative regulation of autophagic vacuole assembly [IMP]
- negative regulation of neuron death [IMP]
- positive regulation of viral release from host cell [IMP]
- posttranslational protein targeting to membrane [IMP]
- protein homooligomerization [IDA]
- regulation of viral process [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epithelial-derived gasdermin D mediates nonlytic IL-1? release during experimental colitis.
Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of IL-1?. Here, we report a nonpyroptotic role of full-length GSDMD in guiding the release of IL-1?-containing small extracellular vesicles (sEVs) from intestinal epithelial cells (IECs). In response to caspase-8 inflammasome activation, GSDMD, chaperoned by Cdc37/Hsp90, recruits the E3 ... [more]
J Clin Invest Dec. 03, 2019; 130(8);4218-4234 [Pubmed: 32597834]
Throughput
- High Throughput
Curated By
- BioGRID