IL1B
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPK activity [IDA]
- apoptotic process [TAS]
- cell-cell signaling [TAS]
- cellular response to drug [IDA]
- cellular response to mechanical stimulus [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to organic substance [IDA]
- cytokine-mediated signaling pathway [IDA]
- embryo implantation [TAS]
- hyaluronan biosynthetic process [IDA]
- inflammatory response [IDA, NAS]
- lipopolysaccharide-mediated signaling pathway [IDA]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of adiponectin secretion [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of lipid metabolic process [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- positive regulation of JNK cascade [IBA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell mediated immunity [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of angiogenesis [ISS]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of cell adhesion molecule production [NAS]
- positive regulation of fever generation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA, NAS]
- positive regulation of histone acetylation [NAS]
- positive regulation of histone phosphorylation [NAS]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-6 production [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of lipid catabolic process [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myosin light chain kinase activity [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of prostaglandin secretion [ISS]
- positive regulation of protein export from nucleus [NAS]
- positive regulation of protein phosphorylation [IDA, NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, ISS]
- protein kinase B signaling [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of insulin secretion [IDA]
- sequestering of triglyceride [IDA]
- signal transduction [TAS]
- smooth muscle adaptation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epithelial-derived gasdermin D mediates nonlytic IL-1? release during experimental colitis.
Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of IL-1?. Here, we report a nonpyroptotic role of full-length GSDMD in guiding the release of IL-1?-containing small extracellular vesicles (sEVs) from intestinal epithelial cells (IECs). In response to caspase-8 inflammasome activation, GSDMD, chaperoned by Cdc37/Hsp90, recruits the E3 ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL1B HSP90AA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID