BAIT
NR4A1
GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
nuclear receptor subfamily 4, group A, member 1
GO Process (16)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration involved in sprouting angiogenesis [IDA]
- cellular response to fibroblast growth factor stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- endothelial cell chemotaxis [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- intracellular receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA]
- nuclear membrane [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, ISS]
Homo sapiens
PREY
DDX5
G17P1, HLR1, HUMP68, p68
DEAD (Asp-Glu-Ala-Asp) box helicase 5
GO Process (11)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- cell growth [NAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- mRNA splicing, via spliceosome [IC]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of intracellular estrogen receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- regulation of androgen receptor signaling pathway [IMP]
- regulation of osteoblast differentiation [ISS]
- regulation of skeletal muscle cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Blocking PPAR? interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
Nuclear receptor Nur77 participates in multiple metabolic regulations and plays paradoxical roles in tumorigeneses. Herein, we demonstrated that the knockout of Nur77 stimulated mammary tumor development in two mouse models, which would be reversed by a specific reexpression of Nur77 in mammary tissues. Mechanistically, Nur77 interacted and recruited corepressors, the SWI/SNF complex, to the promoters of CD36 and FABP4 to ... [more]
Proc Natl Acad Sci U S A Dec. 03, 2019; 117(44);27412-27422 [Pubmed: 33087562]
Throughput
- High Throughput
Curated By
- BioGRID