BAIT
ELOVL5
HELO1, SCA38, dJ483K16.1, RP3-483K16.1
ELOVL fatty acid elongase 5
GO Process (10)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- alpha-linolenic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- fatty acid elongation, monounsaturated fatty acid [IDA]
- fatty acid elongation, polyunsaturated fatty acid [IDA]
- linoleic acid metabolic process [TAS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
- very long-chain fatty acid biosynthetic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACSL3
ACS3, FACL3, PRO2194
acyl-CoA synthetase long-chain family member 3
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- long-chain fatty acid import [IDA]
- long-chain fatty acid metabolic process [IMP]
- positive regulation of Golgi to plasma membrane protein transport [IMP]
- positive regulation of phosphatidylcholine biosynthetic process [IMP]
- positive regulation of secretion [IMP]
- very-low-density lipoprotein particle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 24.59 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID