ADAM15
Gene Ontology Biological Process
- apoptotic process [IDA]
- cell-matrix adhesion [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- innate immune response [IDA]
- integrin-mediated signaling pathway [IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of receptor binding [IMP]
- protein kinase C signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAD2L1
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IDA, IGI]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of mitotic anaphase-promoting complex activity [IDA]
- negative regulation of mitotic cell cycle [IMP]
- negative regulation of protein catabolic process [IDA]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The adamalysins (ADAMs) are transmembrane glycoproteins involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. Many ADAM cytoplasmic domains are proline-rich and have potential phosphorylation sites. We show here that the cytoplasmic domain of ADAM15, metargidin, can interact specifically with Src family protein-tyrosine kinases (PTKs) and the adaptor protein Grb2 in hematopoietic cells (Jurkat, THP-1, U937, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID